I haven't read that Penrose book. I have read some of David Bohm's works and am intrigued by his "active information" which John Polkinghorne also picked up on. I see this in relation to the idea of dual aspect monism which I have explored quite a bit. Active information can help explain the relationships and context you are talking about it seems. Also, Carlos Rovelli has developed the idea of relationships to the point where it is the relationships that are the ontological primitive, the foundation, and not matter per se. So there are some interesting ideas along this line. My own view is formed a lot by Sir Arthur Eddington who considered this and believed there is an underlying unity, which Bohm called the "holomovement" movement of the whole, and Eddington called the Spirit.